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Legend. Physical examination showed a palpable abdominal mass and a normal laboratory data. Abdominal computed tomography (Figure A, B, red arrows) revealed a large, encapsulated and hypervascular space-occupying lesion with cystic component in right lower quadrant of abdomen (7.6 × 5.0 cm in size).

Taipei Medical University Hospital has achieved a breakthrough in Castleman Disease while treating a 20-year-old patient. This case study was interdisciplinary team cooperation between the Division of General Surgery (clinical) and the Division of Colorectal Surgery (research). Their paper has been accepted by the renowned journal, Gastroenterology.

The patient, a young woman, was experiencing constipation for 6 months had tried home remedies without success. The right side of her stomach became distended, so she sought treatment at the Taipei Medical University Hospital.

The examination showed that the patient had a tumor in her abdominal cavity. Its compression on the gastrointestinal tract resulted in constipation. After surgical removal, biopsy indicated that the tumor was a rare unicentric lymphoproliferative disease (aka. Castleman Disease).

After the surgical removal of the tumor, the patient recovered well. Outpatient follow-up showed no recurrence, indicating surgical removal as the main method of treatment.

Castleman Disease is often discovered in routine chest X-rays. If a posterior abdominal cavity mass is found in young patients, Castleman Disease should also be regarded as a possible diagnosis.

In terms of treatment and prognosis, the localized type is a self-limiting disease and prognosis is good. Only surgical removal is needed. The systemic symptoms will disappear immediately after surgery and rarely recur. Therefore those with long-term constipation, abdominal distension, or abnormal weight changes should immediately seek medical attention to rule out the risk of tumors.


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